52 | What Do Your Muscles Have to Do With Your Brain?

When we think about maintaining muscle as we age, we usually focus on strength, balance, mobility, and independence. But what if our muscles are doing more than helping us move?

Researchers are discovering that our muscles communicate with other parts of our body, including our brain, through a process called muscle–brain crosstalk. This emerging area of research is revealing fascinating connections between muscle activity, memory, mood, and cognitive health.

In this episode of RenewHer, we explore what scientists are learning about this connection, why strength training may benefit more than just our muscles, and what these discoveries could mean for women over 50.

What We'll Discuss

  • What muscle–brain crosstalk is and how it works
  • How muscle activity may influence memory, learning, and mood
  • What research suggests about strength training and cognitive function
  • Why maintaining muscle becomes increasingly important as we age
  • Practical ways to support muscle strength and brain health

Key Takeaway

Our muscles do much more than help us move. They're part of a complex communication system that may also influence our brain health. While researchers are still uncovering exactly how this connection works, maintaining muscle strength is another important way to support healthy aging.

If this conversation encouraged you to embrace a new challenge or rediscover a passion, I'd love for you to:

  • Follow RenewHer so you never miss an episode.
  • Leave a rating and review—it helps more women discover the show.
  • Share this episode with a friend who may be wondering what's next after 50.

Remember, it's never too late to learn something new, chase a dream, or begin again. Your next chapter may be your most fulfilling one yet.

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Research & Resources

Muscle–Brain Crosstalk Mediated by Exercise-Induced Myokines (2024)

Crosstalk Between Skeletal Muscle and the Brain During Physical Activity (2025)

A Systematic Review and Meta-Analysis of the Effects of Resistance Exercise on Cognitive Function in Older Adults (2025)

Resistance Training Improves Cognitive Function in Older Adults With Different Cognitive Status (2022)

CDC: Physical Activity Guidelines for Adults